BDBM180270 US9133162, Example 1

SMILES Cc1c(C(=O)Nc2ccc(Oc3ccnc4cc(OCC(C)(C)O)ccc34)c(F)c2)c(=O)n(-c2ccccc2)n1C

InChI Key InChIKey=VQYYQSZNRVQLIS-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 180270   

TargetHepatocyte growth factor receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50: 19nMpH: 7.0 T: 2°CAssay Description:Met (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKSPGEYVNIEFG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50: 37nMpH: 7.0 T: 2°CAssay Description:KDR (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM MgAcetate and [γ-33P-ATP] (specific activity app...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50: 11nMpH: 7.0 T: 2°CAssay Description:Axl (h) is incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKSRGDYMTMQIG, 10 mM MgAcetate and [γ-33P-ATP] (specific activity approx. 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetHepatocyte growth factor receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50: 68nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50: 6.70nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM180270(US9133162, Example 1)
Affinity DataIC50: 33nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed