BDBM180094 US9676721, 77 2-cyano-1-[(4-{[4-(propan-2-yloxy)benzene]sulfonyl}phenyl)methyl]-3-(pyridin-4-yl)guanidine

SMILES CC(C)Oc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1

InChI Key InChIKey=UBZPAWRHSBXZLH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180094   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM180094(US9676721, 77 2-cyano-1-[(4-{[4-(propan-2-yloxy)be...)
Affinity DataIC50: 2.60nMpH: 7.5 T: 2°CAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
Go to US Patent