BDBM180076 US9133148, 10e

SMILES Cn1cc(CN2CCN(CC2)C(=O)OC(C(F)(F)F)C(F)(F)F)c(n1)-c1ccccc1

InChI Key InChIKey=OSSPGACQULABQH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 180076   

TargetFatty-acid amide hydrolase 1(Mouse)
The Scripps Research Institute

US Patent
LigandPNGBDBM180076(US9133148, 10e)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetPlatelet-activating factor acetylhydrolase(Human)
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180076(US9133148, 10e)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PLA2G7 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180076(US9133148, 10e)
Affinity DataIC50: 20nMAssay Description:Inhibition of MGLL derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMonoacylglycerol lipase ABHD6(Human)
Abide Therapeutics

Curated by ChEMBL
LigandPNGBDBM180076(US9133148, 10e)
Affinity DataIC50: 130nMAssay Description:Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed