BDBM179950 US9133148, 3a

SMILES FC(F)(F)C(OC(=O)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1)C(F)(F)F

InChI Key InChIKey=AVSCNEOUWSVZEY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 179950   

TargetFatty-acid amide hydrolase 1(Mouse)
The Scripps Research Institute

US Patent
LigandPNGBDBM179950(US9133148, 3a)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM179950(US9133148, 3a)
Affinity DataIC50: 74nMAssay Description:Inhibition of human recombinant MAGL expressed in HEK293 cells using 2-AG as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2016
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Eastern Finland

Curated by ChEMBL
LigandPNGBDBM179950(US9133148, 3a)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human full length MAGL expressed in HEK293 cells preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179950(US9133148, 3a)
Affinity DataIC50: 14nMAssay Description:Inhibition of rat MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179950(US9133148, 3a)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of mouse MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed