BDBM179929 US9133148, 1a

SMILES OC(C1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)(c1ccc2OCOc2c1)c1ccc2OCOc2c1

InChI Key InChIKey=SXHQLPHDBLTFPM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 179929   

TargetFatty-acid amide hydrolase 1(Mouse)
The Scripps Research Institute

US Patent
LigandPNGBDBM179929(US9133148, 1a)
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:Proteomes (mouse brain membrane fraction or cell lysates) (50 uL, 1.0 mg/mL total protein concentration) were preincubated with varying concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2016
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179929(US9133148, 1a)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant human full length MAGL expressed in HEK293 cells preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Rat)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179929(US9133148, 1a)
Affinity DataIC50: 43nMAssay Description:Inhibition of rat MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Mouse)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179929(US9133148, 1a)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse MAGL preincubated for 30 mins followed by FP-Rh addition after 30 mins by gel-based ABPP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179929(US9133148, 1a)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant MAGL using 4-NPA as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM179929(US9133148, 1a)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human MAGL transfected in human HEK293T cells assessed as reduction in ABPP binding by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed