BDBM179801 3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine (9)

SMILES Fc1ccc(Cl)c(Sc2n[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)c1Cl

InChI Key InChIKey=FCLVBOUURHAHBG-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 179801   

TargetIsoform 2 of Hepatocyte growth factor receptor (2)(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 22.8nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 135nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor [C1156Y](Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 651nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor [L1196M](Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 578nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 23nMAssay Description:Inhibition of c-Met (unknown origin) using Tyr 6 peptide as substrate incubated for 90 mins in presence of ATP by FRET based Z-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant c-Met (unknown origin) using poly Tyrosine peptide as substrate in presence of ATP incubated for 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 135nMAssay Description:Inhibition of wild type ALK (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 651nMAssay Description:Inhibition of ALK C1156Y mutant (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Tianjin University of Science and Technology

LigandPNGBDBM179801(3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperi...)
Affinity DataIC50: 578nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed