BDBM178166 US10307413, Compound 208::US10391089, Compound 208::US10980794, Cmpd No 208::US11591326, Compound C3::US20250051307, Example GSK3326595::US9675614, 208
SMILES CC(=O)N1CCC(CC1)Nc2cc(ncn2)C(=O)NC[C@@H](CN3CCc4ccccc4C3)O
InChI Key InChIKey=JLCCNYVTIWRPIZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 178166
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PRMT5 (unknown origin)/MEP50 (unknown origin) using histone H4 as substrate preincubated for 60 mins in presence of enzyme and SAMMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of PRMT5 methyltransferase activity in MTAP knockout human HCT-116 cells assessed as inhibition of PRMT5- mediated SDMA modification level...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of PRMT5 methyltransferase activity in human HCT-116 cells expressing wild type MTAP assessed as inhibition of PRMT5- mediated SDMA modifi...More data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:General Procedure for PRMT5/MEP50 AlphaLISA Enzyme Inhibitory Assays: Assays were performed in the buffer consisting of 50 mM Tris, pH 8.5, 5 mM MgCl...More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:After dissolved in dimethyl sulfoxide respectively, the test compounds were added into an Echo Qualified 384-well plate and diluted to the desired co...More data for this Ligand-Target Pair