BDBM17807 benzimidazole-urea, 34::methyl N-(6-{[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]sulfanyl}-1H-1,3-benzodiazol-2-yl)carbamate

SMILES COC(=O)Nc1nc2ccc(Sc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1

InChI Key InChIKey=KBJVFZCXZGSCFO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 17807   

TargetAngiopoietin-1 receptor(Human)
Gsk

LigandPNGBDBM17807(methyl N-(6-{[4-({[2-fluoro-5-(trifluoromethyl)phe...)
Affinity DataIC50: 10nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17807(methyl N-(6-{[4-({[2-fluoro-5-(trifluoromethyl)phe...)
Affinity DataIC50: 10nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM17807(methyl N-(6-{[4-({[2-fluoro-5-(trifluoromethyl)phe...)
Affinity DataIC50: 340nMAssay Description:Inhibitory activity against recombinant matrix metalloprotease-1 (MMP-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed