BDBM17789 benzimidazole-urea, 17::methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1H-1,3-benzodiazol-2-yl}carbamate

SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1

InChI Key InChIKey=KADQEUOYNAPXRD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17789   

TargetAngiopoietin-1 receptor(Human)
Gsk

LigandPNGBDBM17789(methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phen...)
Affinity DataIC50: 6.90nMpH: 7.4 T: 2°CAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
LigandPNGBDBM17789(methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phen...)
Affinity DataIC50: 3.5nMAssay Description:The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM17789(methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phen...)
Affinity DataIC50: 695nMAssay Description:Inhibition of c-Raf kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Gsk

LigandPNGBDBM17789(methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phen...)
Affinity DataIC50: 10nMAssay Description:Inhibition of Tie2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2011
Entry Details Article
PubMed