BDBM17759 (2S)-2-(phosphonomethyl)pentanedioic acid::(S)-2-PMPA::pentanedioic acid analogue, (S)-1

SMILES OC(=O)CC[C@H](CP(O)(O)=O)C(O)=O

InChI Key InChIKey=ISEYJGQFXSTPMQ-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 17759   

TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataIC50: 0.100nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataIC50: 94nMAssay Description:Inhibition of GCPII (unknown origin) expressed in DU-145 cells after 2 hrs by Amplex red reagent based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataIC50: 80nMAssay Description:Inhibition of PSMA in human LNCaP cell extracts using NAAG as substrate by amplex red reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetGlutamate carboxypeptidase 2(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to NAALADaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
King'S College London

Curated by ChEMBL
LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of GCPII (unknown origin) NAALADase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed