BDBM17746 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({3-fluoro-4-[3-(piperidin-1-yl)propoxy]phenyl}amino)pyrimidin-4-yl]carbamate::2-aminopyrimidine carbamate, 45

SMILES COc1ccc(N(C(=O)Oc2c(C)cccc2C)c2ccnc(Nc3ccc(OCCCN4CCCCC4)c(F)c3)n2)c(OC)c1

InChI Key InChIKey=XCEDFZFYFQZOMX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17746   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM17746(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed
LigandPNGBDBM17746(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50: 12nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed
LigandPNGBDBM17746(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50: 6.80E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed
LigandPNGBDBM17746(2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-({...)
Affinity DataIC50: 620nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed