BDBM1774 US10894048, Ref. Ex Comp. 1::US8476284, 13

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C

InChI Key InChIKey=XYFPWWZEPKGCCK-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 1774   

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full-length N-terminal GST tagged BTK (1 to 659 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged full length BLK expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged full length ITK expressed in baculovirus expression system incubated for 1 hr by Z'lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human His-tagged LCK expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged ERBB4 catalytic domain expressed in baculovirus expression system incubated for 1 hr by Z'-LYTE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 expressed in baculovirus expression system incubated for 1 hr by Z'lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of N-terminal GST-tagged ITK (2 to 620 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of N-terminal GST-tagged BMX (1 to 675 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal DYKDDDD-tagged EGFR (669 to 1210 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:Measurements were performed in a reaction volume of 50 μL using 96-well assay plates. Kinase enzyme, inhibitor, ATP (at the Km for the kinase), an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2013
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 19nMAssay Description:Inhibition of human BTK using poly (Glu,Tyr) as substrate in presence of ATP and Ci(gamma33-P) ATP measured by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 280nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of BTK (unknown origin) after 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BTK (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 11nMAssay Description:Inhibition of ITK (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 78nMAssay Description:Inhibition of TEC (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Shaanxi University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM1774(US8476284, 13 | US10894048, Ref. Ex Comp. 1)
Affinity DataIC50: 200nMAssay Description:Inhibition of LYN (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed