BDBM17725 2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-N-phenylcarbamate::2-aminopyrimidine carbamate, 1

SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)N(C(=O)Oc2c(C)cccc2C)c2ccccc2)cc1

InChI Key InChIKey=JHOJBACWBQNOPM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17725   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM17725(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed
LigandPNGBDBM17725(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 10nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed
LigandPNGBDBM17725(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 160nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed
LigandPNGBDBM17725(2,6-dimethylphenyl N-(2-{[4-(4-methylpiperazin-1-y...)
Affinity DataIC50: 190nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2007
Entry Details Article
PubMed