BDBM175901 US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-phenyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine

SMILES CCCCOc1ccc(cc1)C1N(Cc2ccccc2)CCn2nnnc12

InChI Key InChIKey=GJKBDIQPAZDQPN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 175901   

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175901(US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-pheny...)
Affinity DataIC50: 500nMpH: 6.8Assay Description:In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175901(US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-pheny...)
Affinity DataIC50: 5.45E+3nMAssay Description:For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175901(US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-pheny...)
Affinity DataIC50: 500nMpH: 6.8Assay Description:In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175901(US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-pheny...)
Affinity DataIC50: 5.45E+3nMAssay Description:For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma [238-497](Human)
Merck Patent

US Patent
LigandPNGBDBM175901(US9688684, Compound 98: 7-Benzyl-8-(4-butoxy-pheny...)
Affinity DataIC50: 2.50E+4nMpH: 6.8Assay Description:In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2018
Entry Details
Go to US Patent