BDBM174827 US10053462, 58::US9102686, 58::US9540388, 58

SMILES FC(F)(F)c1cccc(C(=O)N2[C@H]3CC[C@@H]2c2nnc(-c4ccsc4)n2C3)c1Cl

InChI Key InChIKey=JKORAOINNUXQPA-UHFFFAOYSA-N

Data  5 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 174827   

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataIC50: 713nMpH: 7.4Assay Description:Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataIC50: 713nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataKi:  10nMAssay Description:Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2016
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataKi:  10nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataKi:  10nM IC50: 1.00E+4nMAssay Description:human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataKi:  10nM IC50: 1.70nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174827(US9102686, 58 | US9540388, 58 | US10053462, 58)
Affinity DataKi:  10nM IC50: 713nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent