BDBM17459 1,2,3-triazole analogue, 15::5-(4-chlorophenyl)-1H-1,2,3-triazole

SMILES Clc1ccc(cc1)-c1c[nH]nn1

InChI Key InChIKey=CGWXLIIVSXHAOP-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17459   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17459(5-(4-chlorophenyl)-1H-1,2,3-triazole | 1,2,3-triaz...)
Affinity DataIC50: 8.17E+5nMAssay Description:Inhibition of human recombinant indoleamine-2,3-dioxygenase expressed in Escherichia coli BL21 using L-tryptophan as substrate after 30 mins by micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM17459(5-(4-chlorophenyl)-1H-1,2,3-triazole | 1,2,3-triaz...)
Affinity DataIC50: 5.30E+5nMpH: 6.5Assay Description:Inhibition of human recombinant N-terminal His-tagged IDO1 (Ala2 to Gly403) overexpressed in Escherichia coli BL21 at pH 6.5 after 60 mins by HPLC an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Human)
University College London

Curated by ChEMBL
LigandPNGBDBM17459(5-(4-chlorophenyl)-1H-1,2,3-triazole | 1,2,3-triaz...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human Notum (S81-T451 residues) C330S mutant expressed in HEK293S cells using OPTS substrate incubated for 40 mins by fluorescence base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM17459(5-(4-chlorophenyl)-1H-1,2,3-triazole | 1,2,3-triaz...)
Affinity DataKi:  6nM ΔG°:  -11.1kcal/molepH: 7.5 T: 2°CAssay Description:MetAP2 activity was monitored by measuring the initial velocity of turnover of the artificial substrate Met-AMC. Assays were performed in 96-well mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2007
Entry Details Article
PubMed