BDBM17279 2-(5-carbamimidoyl-2-hydroxyphenoxy)-6-[3-(4,5-dihydro-1H-imidazol-2-yl)phenoxy]pyridine-4-carboxylic acid::CHEMBL315014::Pyridine template, IV::ZK-806688

SMILES NC(=N)c1ccc(O)c(Oc2cc(cc(Oc3cccc(c3)C3=NCCN3)n2)C(O)=O)c1

InChI Key InChIKey=KDDSLUYCOZXRQI-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 17279   

TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  85nM ΔG°:  -9.54kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  85nM ΔG°:  -9.54kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  85nMAssay Description:Inhibitory potency was measured against human coagulation factor XMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  85nMAssay Description:Inhibition of human Coagulation factor X was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  85nMAssay Description:Inhibitory constant against human coagulation factor Xa (fXa)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  1.40E+3nM ΔG°:  -7.90kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  1.40E+3nM ΔG°:  -7.90kcal/molepH: 7.5 T: 2°CAssay Description:The enzyme activities were determined kinetically as the initial rate of cleavage of a peptide p-nitroanilide. Km for enzyme and substrate was determ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2007
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Berlex

LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory potency was measured against bovine trypsin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory constant against bovine trypsin for general specificity against serine proteasesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory potency was measured against human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM17279(CHEMBL315014 | 2-(5-carbamimidoyl-2-hydroxyphenoxy...)
Affinity DataKi: >5.00E+3nMAssay Description:Inhibitory constant against human coagulation factor II (thrombin) for selectivity within coagulation cascadeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed