BDBM172764 US10774056, Compound 021::US11542242, Compound 021::US9096549, K

SMILES Nc1ccccc1NC(=O)c1cc2ccc(cc2cn1)N1CCNCC1

InChI Key InChIKey=QBVCDTAHPQAPDK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 172764   

TargetHistone deacetylase 1(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM172764(US9096549, K | US10774056, Compound 021 | US115422...)
Affinity DataIC50: 299nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 2(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM172764(US9096549, K | US10774056, Compound 021 | US115422...)
Affinity DataIC50: 271nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 3(Human)
Acetylon Pharmaceuticals

US Patent
LigandPNGBDBM172764(US9096549, K | US10774056, Compound 021 | US115422...)
Affinity DataIC50: 38nMpH: 7.4Assay Description:Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM172764(US9096549, K | US10774056, Compound 021 | US115422...)
Affinity DataIC50: 4.20E+3nMAssay Description:For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM172764(US9096549, K | US10774056, Compound 021 | US115422...)
Affinity DataIC50: 4.20E+3nMAssay Description:For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent