BDBM172715 US9090657, DEBIO-025, 2

SMILES CCC1NC(=O)C(C(O)C(C)C\C=C\C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(C(C)C)N(CC)C(=O)C(C)N(C)C1=O)C(C)C

InChI Key InChIKey=OLROWHGDTNFZBH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 172715   

TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 0.800nMAssay Description:The PPlase activity of recombinant CypA or D, produced by thrombin cleavage of GST-CypA or D, was determined by following the rate of hydrolysis of N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetSolute carrier organic anion transporter family member 1B1(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 450nMpH: 7.3 T: 2°CAssay Description:To assess the inhibition of the OAT1B1 and OAT1B3 uptake transporters, an in vitro uptake transporter assay from Solvo Biotechnology Inc. was used. U...More data for this Ligand-Target Pair
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Date in BDB:
3/21/2016
Entry Details
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TargetSolute carrier organic anion transporter family member 1B3(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 190nMpH: 7.3 T: 2°CAssay Description:To assess the inhibition of the OAT1B1 and OAT1B3 uptake transporters, an in vitro uptake transporter assay from Solvo Biotechnology Inc. was used. U...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetATP-binding cassette sub-family C member 2(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 1.60E+4nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetATP-binding cassette sub-family C member 2(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 5.00E+4nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetATP-dependent translocase ABCB1(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 720nMpH: 7.4 T: 2°CAssay Description:To assess the inhibition of the P-glycoprotein (Pgp/MDR1) transporter, an in vitro ATPase assay from Cyprotex was used. MDR1MDCK cells obtained from ...More data for this Ligand-Target Pair
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Date in BDB:
3/21/2016
Entry Details
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TargetBile salt export pump(Human)
Neurovive Pharmaceutical

US Patent
LigandPNGBDBM172715(US9090657, DEBIO-025, 2)
Affinity DataIC50: 180nMT: 2°CAssay Description:To assess the inhibition of the MRP2, MRP3 and BSEP efflux transporters, an in vitro vesicular transporter assay from Solvo Biotechnology Inc. was us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
Go to US Patent