BDBM172394 US9090618, O85d::US9598411, Ref. No. O85d

SMILES OC(=O)CN1\C(N([C@@H]2C[C@@H]3CCC[C@H](C2)N3[C@H]2C[C@@H]3C[C@H](C2)CCCC3)c2ccccc12)=C1\CCCN(CC(O)=O)C1

InChI Key

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 172394   

TargetOpioid growth factor receptor-like protein 1(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  21.7nM ΔG°:  -10.4kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays (screening and dose-displacement) used 0.1 nM [3H]-nociceptin (NEN; 87.7 Ci/mmole) with 10-20 ug membrane protein in a fin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetNociceptin receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  21.7nMAssay Description:δ-Opioid Receptor Binding Assay Procedures: Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  41.3nMpH: 7.4Assay Description:Radioligand dose displacement assays used 0.4-0.8 nM [3H]-U69,593 (NEN; 40 Ci/mmole) with 10-20 μg membrane protein (recombinant kappa opioid re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetKappa-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  41.3nMAssay Description:μ-Opioid Receptor Binding Assay Procedures: Radioligand binding assays were conducted using freshly thawed membranes expressing human μ-rec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetDelta-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  76nMAssay Description:ORL-1 Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human opioid receptor-like receptor (ORL-1) (Recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  390nMAssay Description:κ-Opioid Receptor Binding Assay Procedures: Membranes from recombinant HEK-293 cells expressing the human kappa opioid receptor (kappa) (cloned ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
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TargetMu-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  1.18E+4nM ΔG°:  -6.72kcal/molepH: 7.4 T: 2°CAssay Description:Radioligand binding assays were conducted using freshly thawed membranes expressing human mu-receptors (Perkin Elmer, Shelton, Conn.). Radioligand do...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
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TargetDelta-type opioid receptor(Human)
Purdue Pharma

US Patent
LigandPNGBDBM172394(US9090618, O85d | US9598411, Ref. No. O85d)
Affinity DataKi:  1.21E+4nMpH: 7.4Assay Description:Radioligand dose-displacement assays used 0.2 nM [3H]-Naltrindole (NEN; 33.0 Ci/mmole) with 10-20 μg membrane protein (recombinant delta opioid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
Go to US Patent