BDBM172197 US9090564, 11::US9096594, 54

SMILES CN(C)C(=O)c1ccc(cc1Cl)-c1ccnc(C)c1C#Cc1ccc(N)nc1

InChI Key InChIKey=MNHCYTKOZZNQIL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 172197   

TargetCyclin-A2 [177-432]/Cyclin-dependent kinase 2(Human)
The Broad Institute

US Patent
LigandPNGBDBM172197(US9096594, 54 | US9090564, 11)
Affinity DataIC50: 3.90E+3nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
The Broad Institute

US Patent
LigandPNGBDBM172197(US9096594, 54 | US9090564, 11)
Affinity DataIC50: 4.40E+3nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM172197(US9096594, 54 | US9090564, 11)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Kinase reaction conditions:400 nM GFP-4E-BP1, 8 uM ATP, -150 ng/mL mTOR, 50 mM HEPES pH 7.5, 0.01% Polysorbate 20, 1 mM EGTA, 10 mM MnC12, and variab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
Go to US Patent