BDBM172196 US9090564, 10::US9096594, 22

SMILES Cc1nccc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c1C#Cc1ccc(N)nc1

InChI Key InChIKey=UDIUKSLSDVCBFN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 172196   

TargetCyclin-A2 [177-432]/Cyclin-dependent kinase 2(Human)
The Broad Institute

US Patent
LigandPNGBDBM172196(US9096594, 22 | US9090564, 10)
Affinity DataIC50: 1.50E+3nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
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TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
The Broad Institute

US Patent
LigandPNGBDBM172196(US9096594, 22 | US9090564, 10)
Affinity DataIC50: 2.20E+3nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM172196(US9096594, 22 | US9090564, 10)
Affinity DataIC50: 27nMT: 2°CAssay Description:The GSK3beta primary screen was conducted in assay ready 1536 plates (Aurora 29847) that contain 2.5 mL/well of 10 mM compound. Human GSK3beta as a G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM172196(US9096594, 22 | US9090564, 10)
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:Kinase reaction conditions:400 nM GFP-4E-BP1, 8 uM ATP, -150 ng/mL mTOR, 50 mM HEPES pH 7.5, 0.01% Polysorbate 20, 1 mM EGTA, 10 mM MnC12, and variab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details
Go to US Patent