BDBM171268 US9085555, 698
SMILES C[C@H](NC(=O)[C@@H]1C[C@H]2C[C@H]2N1C(=O)Cn1nc(C(N)=O)c2ccncc12)c1cccc(Cl)c1F
InChI Key InChIKey=YAALCKJNOOFODD-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 171268
Affinity DataIC50: 29nMpH: 7.5 T: 2°CAssay Description:Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of human factor D using CVF-FB as substrate assessed as decrease in formation of factor B cleavage product Ba by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of factor D in human serum assessed as decrease in lysis of human erythrocytes after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of factor D in human serum assessed as decrease in C3 deposition on human erythrocytes after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 144nMAssay Description:Inhibition of factor D in human plasma assessed as decrease in alternative pathway-mediated MAC formation preincubated for 30 mins measured after 30 ...More data for this Ligand-Target Pair