BDBM16919 3-[(2S)-2-amino-3-[(5-{thieno[2,3-c]pyridin-2-yl}pyridin-3-yl)oxy]propyl]-1H-indole::Biochemistry 469551 Compound 12::CHEMBL516429::thieno[2,3-c]pyridine, 9a

SMILES N[C@H](COc1cncc(c1)-c1cc2ccncc2s1)Cc1c[nH]c2ccccc12

InChI Key InChIKey=GWJHMRBQEUHFOC-UHFFFAOYSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 16919   

LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataIC50: 5.40nMpH: 7.5 T: 2°CAssay Description:The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2007
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataIC50: 179nMAssay Description:Inhibition of AktMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Abbott Laboratories

LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataKi:  440nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK2(Human)
Abbott Laboratories

LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataKi:  980nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
Abbott Laboratories

LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataKi:  2.70E+3nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM16919(Biochemistry 469551 Compound 12 | CHEMBL516429 | 3...)
Affinity DataKi:  1.00E+4nM ΔG°:  -6.75kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2008
Entry Details Article
PubMed