BDBM168632 US9079866, 5::US9745328, Compound 5::US9884878, Compound 5

SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(N)(=O)=O

InChI Key InChIKey=SXONKUBZFICRAY-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168632   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM168632(US9079866, 5 | US9884878, Compound 5 | US9745328, ...)
Affinity DataIC50: 390nMAssay Description:Inhibition of FLAP in human whole blood assessed as reduction in LTB4 level preincubated for 15 mins followed by calcium ionophore A23187 addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM168632(US9079866, 5 | US9884878, Compound 5 | US9745328, ...)
Affinity DataKi:  35nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
Go to US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Gazi University

Curated by ChEMBL
LigandPNGBDBM168632(US9079866, 5 | US9884878, Compound 5 | US9745328, ...)
Affinity DataKi:  35nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
Go to US Patent

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168632(US9079866, 5 | US9884878, Compound 5 | US9745328, ...)
Affinity DataKi:  35nMAssay Description:The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
Go to US Patent