BDBM168619 US20240360091, Compound (10075)S::US9079852, Table F, Compound 4

SMILES NC(=O)Nc1ccc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=GSOWCEUNQPJIFR-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168619   

TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rat)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4 | US20240360091, Co...)
Affinity DataIC50: 340nMAssay Description:Binding to the rat alpha-1 adrenergic receptor in rat brain membranes was determined by displacement of 3[H]-prazosin (P. Greengrass and R. Bremner; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
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TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4 | US20240360091, Co...)
Affinity DataIC50: 46nMAssay Description:The GluN2B potency and pH dependence of NP10679, NP10309, and other compounds in Tables 1 and 2 were evaluated on human GluN1-la/GluN2B receptors (he...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
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TargetGlutamate receptor ionotropic, NMDA 2B(Human)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4 | US20240360091, Co...)
Affinity DataIC50: 452nMAssay Description:The GluN2B potency and pH dependence of NP10679, NP10309, and other compounds in Tables 1 and 2 were evaluated on human GluN1-la/GluN2B receptors (he...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2025
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emory University

US Patent
LigandPNGBDBM168619(US9079852, Table F, Compound 4 | US20240360091, Co...)
Affinity DataKi:  1.30E+4nMAssay Description:Compounds were evaluated for binding to the human ether-a-go-go potassium channel (hERG) expressed in HEK293 cells by displacement of 3[H]-astemizole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
Go to US Patent