BDBM168184 US9688642, 15::US9688642, 30

SMILES COc1cc(c(F)cn1)-c1ncc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)nc1C1=CCCC1(C)C

InChI Key InChIKey=NEANWAJDBGJJSW-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 168184   

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168184(US9688642, 15 | US9688642, 30)
Affinity DataEC50:  11nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168184(US9688642, 15 | US9688642, 30)
Affinity DataEC50:  18nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168184(US9688642, 15 | US9688642, 30)
Affinity DataEC50:  37nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
Go to US Patent

TargetFree fatty acid receptor 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168184(US9688642, 15 | US9688642, 30)
Affinity DataEC50:  201nMT: 2°CAssay Description:Compounds were tested in a calcium flux assay using transfected HEK293 cells stably expressing either human GPR40 or rat GPR40. Human GPR40 expressin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2018
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Rat)
Janssen Research & Developmen

Curated by ChEMBL
LigandPNGBDBM168184(US9688642, 15 | US9688642, 30)
Affinity DataEC50:  18nMAssay Description:Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM168184(US9688642, 15 | US9688642, 30)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed