BDBM167798 US9073922, 289::US9796708, Example 289

SMILES COc1ccc(F)cc1-c1ccnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@H](CC(O)=O)CC1

InChI Key InChIKey=DZZGVCFHAAYUAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 167798   

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167798(US9073922, 289 | US9796708, Example 289)
Affinity DataIC50: 57nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167798(US9073922, 289 | US9796708, Example 289)
Affinity DataIC50: 57nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167798(US9073922, 289 | US9796708, Example 289)
Affinity DataIC50: 200nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate measured after 1.5 hrs by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM167798(US9073922, 289 | US9796708, Example 289)
Affinity DataIC50: 350nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at C-terminal ser2 residue incubated for 4 hrs by In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed