BDBM16756 3-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(dipropylcarbamoyl)phenyl]formamido}-2-ethyl-4-hydroxyhexanamido]propanoic acid::CHEMBL295996::Hydroxyethylene-Based Peptidomimetic Inhibitor, 6

SMILES CCCN(CCC)C(=O)c1cccc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@@H](O)C[C@@H](CC)C(=O)NCCC(O)=O

InChI Key InChIKey=IQPUAQWXFYEAKS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16756   

TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16756(3-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 2.80E+3nMpH: 4.8 T: 2°CAssay Description:Beta-cleavage ELISA assays were carried out in reaction buffer containing enzyme, substrate MBP-C125, and test compounds. Generated beta-cleaved prod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Elan Pharmaceuticals

LigandPNGBDBM16756(3-[(2R,4S,5S)-6-(3,5-difluorophenyl)-5-{[3-(diprop...)
Affinity DataIC50: 2.80E+3nMAssay Description:Binding affinity against Beta-secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2012
Entry Details Article
PubMed