BDBM16755 Acylguanidine, 10d::N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrrol-1-yl]acetamide

SMILES CCCOc1ccc(cc1)-c1ccc(-c2ccccc2Cl)n1CC(=O)NC(=N)NCCCO

InChI Key InChIKey=FDBNUXAMAFEWOP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 16755   

TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 110nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 340nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 5.90E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetPepsin A-4(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human BACE1 by FRETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Wyeth Research

LigandPNGBDBM16755(N-[(1Z)-amino[(3-hydroxypropyl)amino]methylidene]-...)
Affinity DataIC50: 121nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed