BDBM16744 CHEMBL206854::Coumarin Compound, 10b::tert-butyl 4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chromene-3-)amido]phenyl}piperazine-1-carboxylate

SMILES COc1cccc2cc(C(=O)Nc3cc(Br)ccc3N3CCN(CC3)C(=O)OC(C)(C)C)c(=O)oc12

InChI Key InChIKey=MRDWDHZSINJWSN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16744   

TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16744(tert-butyl 4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chrom...)
Affinity DataIC50: 1.00E+3nMAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16744(tert-butyl 4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chrom...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16744(tert-butyl 4-{4-bromo-2-[(8-methoxy-2-oxo-2H-chrom...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed