BDBM167423 US9073893, 23

SMILES NC(=O)c1cc(F)cc2[nH]n(C3CCN(CC3)C3CCCCC3)c(=O)c12

InChI Key InChIKey=OKBDXGNRRUXLQE-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 167423   

TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167423(US9073893, 23)
Affinity DataKd:  30nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 2(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167423(US9073893, 23)
Affinity DataKd:  5.00E+3nMAssay Description:Affinity evaluation of the tested compounds and their selectivity with respect to the different PARP isoforms of interest was assessed in a displacem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Nerviano Medical Sciences

US Patent
LigandPNGBDBM167423(US9073893, 23)
Affinity DataIC50: 340nMT: 2°CAssay Description:Cellular activity of PARP-1 inhibitors was assessed by measuring the inhibition of the hydrogen peroxide induced PAR formation in HeLa cells (ECACC)....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details
Go to US Patent