BDBM16724 CHEMBL381618::Naphthyl Compound, 3b::tert-butyl 4-[4-bromo-2-(naphthalene-1-amido)phenyl]piperazine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(Br)cc1NC(=O)c1cccc2ccccc12

InChI Key InChIKey=YJJFMJAXEJFWKZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16724   

TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16724(CHEMBL381618 | tert-butyl 4-[4-bromo-2-(naphthalen...)
Affinity DataIC50: 1.00E+3nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16724(CHEMBL381618 | tert-butyl 4-[4-bromo-2-(naphthalen...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of BACE1 activity by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Universite De La Mediterranee

LigandPNGBDBM16724(CHEMBL381618 | tert-butyl 4-[4-bromo-2-(naphthalen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed