BDBM166686 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione (F8)

SMILES CC1=CC(=O)C(=CC1=O)C(C)C

InChI Key InChIKey=KEQHJBNSCLWCAE-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 166686   

TargetCaspase-1(Human)
Depaul University

LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: 1.08E+3nMpH: 7.5 T: 2°CAssay Description:All assays were performed at 100 µL total volume in triplicate and monitored for 60 minutes at room temperature in a 96-well plate format in HEPES Bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/29/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: 2.18E+3nMAssay Description:Inhibition of recombinant Plk1 (unknown origin) preincubated for 30 mins before recombinant Cdc25C substrate addition by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase PLK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of recombinant Plk2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant Plk3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMed
TargetEukaryotic elongation factor 2 kinase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM166686(2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-di...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of eEF2K (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed