BDBM16649 2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide::4-Pivaloylamido-benzenesulfonamide::CHEMBL23285::aromatic sulfonamide compound 14

SMILES CC(C)(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=KGBTVIQRHXYTRQ-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 16649   

TargetCarbonic anhydrase 5A, mitochondrial(Mouse)
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  96nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Università

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  136nMAssay Description:Inhibitory activity against human Carbonic anhydrase IX (hCA IX)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  230nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  230nMAssay Description:Inhibitory activity against human Carbonic anhydrase II (hCA II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 12(Human)
Università

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  249nMAssay Description:Inhibitory activity against human Carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 14(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  730nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  2.55E+3nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  7.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  2.06E+4nM ΔG°:  -6.39kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2007
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | CH...)
Affinity DataKi:  2.06E+4nMAssay Description:Inhibitory activity against human Carbonic anhydrase I (hCA I)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed