BDBM165253 US10604504, Example 49::US11623921, Example 49::US9688629, 49::US9802915, Example 49::US9920031, Example 49

SMILES Cc1[nH]c2c(ccc(-c3cccc(c3C)-n3cnc4ccccc4c3=O)c2c1C)C(N)=O

InChI Key InChIKey=NXMFFUWGMHKEJX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 165253   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human full-length His-tagged BTK cytoplasmic domain expressed in baculovirus expression system using fluorescence-labelled ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 12nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2023
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 12nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 12nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 12nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM165253(US9688629, 49 | US9802915, Example 49 | US9920031,...)
Affinity DataIC50: 890nMAssay Description:Inhibition of BTK in human Ramos cells assessed as reduction in intracellular calcium level incubated for 1 hr measured for 180 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed