BDBM164916 US10166239, Ex. 3-24::US11406644, Example 3-24::US9067914, Ex. 3-24

SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C(C)(C)N)cc2OC)cn1

InChI Key InChIKey=VCLCQJKIOXPDMP-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 164916   

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 88nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 43nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 88nMAssay Description:In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 43nMAssay Description:In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 7nMAssay Description:In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 88nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 43nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 7nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2019
Entry Details
Go to US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 88nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Genzyme

US Patent
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 43nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 7nMAssay Description:Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
Go to US Patent

LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM164916(US9067914, Ex. 3-24 | US10166239, Ex. 3-24 | US114...)
Affinity DataIC50: 26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed