BDBM163842 US9062070, 97

SMILES Cc1c(ccc(F)c1[N+]#[C-])[C@H]1CN2CCN(C[C@H]2CN1)C(=O)C1CCc2cc(ncc12)-n1cnnn1

InChI Key InChIKey=IIZMZERPGJMMLW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163842   

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM163842(US9062070, 97)
Affinity DataIC50: 90nMpH: 7.4Assay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM163842(US9062070, 97)
Affinity DataIC50: 160nMT: 2°CAssay Description:The ROMK channel functional thallium flux assay is performed in 384 wells, using the FLIPR-Tetra instrument. HEK-hKir1.1 cells are seeded in Poly-D-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2016
Entry Details
Go to US Patent