BDBM163636 3[(6,8Dimethyl2oxo1,2dihydroquinolin3 yl)methyl]1(4ethoxyphenyl)3(2hydroxyethyl)thiourea (Inh 1)::US9334288, 1
SMILES CCOc1ccc(NC(=S)N(CCO)Cc2cc3cc(C)cc(C)c3[nH]c2=O)cc1
InChI Key InChIKey=PSKUPWXOVUAUJD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 163636
Affinity DataIC50: 283nMAssay Description:PNPG Assay: Two -glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorba...More data for this Ligand-Target Pair
Affinity DataEC50: 17.7nMAssay Description:PNPG Assay: Two -glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorba...More data for this Ligand-Target Pair
Affinity DataIC50: 277nMAssay Description:PheG Assay: Two -glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorba...More data for this Ligand-Target Pair
Affinity DataEC50: 29nMAssay Description:PheG Assay: Two -glucuronidase activity assays were employed to examine the potency of inhibitors both in vitro and in cell-based studies. An absorba...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of beta-glucuronidase (unknown origin)More data for this Ligand-Target Pair
Affinity DataEC50: 18nMAssay Description:Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 164nMAssay Description:In-vivo inhibition of beta-glucuronidase in BALB/CJ mouse at 10 ug administered as twice dailyMore data for this Ligand-Target Pair
Affinity DataKi: 160nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
TargetBeta-galactosidase [V151I,I185V](Clostridium perfringens)
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataKi: 970nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair
TargetBeta-galactosidase(Streptococcus agalactiae (Firmicutes))
University of North Carolina at Chapel Hill
University of North Carolina at Chapel Hill
Affinity DataKi: 1.40E+3nMAssay Description:Reactions were conducted similarly to the kinetic assays but the reaction consisted of 10 µL assay buffer, 5 µL inhibitor solution, 5 µL of 10 nM enz...More data for this Ligand-Target Pair