BDBM163592 US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl]-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine

SMILES Fc1ccc(CNc2nc(nn2C(=O)c2ccccc2)-c2ccccn2)cc1

InChI Key InChIKey=QINGREKOIHZHSD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 163592   

TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163592(US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163592(US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl...)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetCoagulation factor X(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163592(US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl...)
Affinity DataIC50: 2.83E+4nMAssay Description:Inhibition of human factor Xa using S-2765 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetKallikrein-1(Human)
Verseon

US Patent
LigandPNGBDBM163592(US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl...)
Affinity DataIC50: 5.50E+4nMpH: 7.5 T: 2°CAssay Description:Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent