BDBM163457 US9687479, 14 3-(5-[(4-fluorophenyl)methyl]sulfanyl-1-[(2-methoxyphenyl)carbonyl]-1H-1,2,4-triazol-3-yl)pyridine

SMILES COc1ccccc1C(=O)n1nc(nc1SCc1ccc(F)cc1)-c1cccnc1

InChI Key InChIKey=QSXJROHZJFBGNA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 163457   

TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163457(US9687479, 14 3-(5-[(4-fluorophenyl)methyl]sulfany...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163457(US9687479, 14 3-(5-[(4-fluorophenyl)methyl]sulfany...)
Affinity DataIC50: 550nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent

TargetCoagulation factor X(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163457(US9687479, 14 3-(5-[(4-fluorophenyl)methyl]sulfany...)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of human factor Xa using S-2765 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed