BDBM163397 US9687479, 273 1-(5-[(5-chlorothiophen-2-yl)methyl]amino-4-fluoro-3-(oxan-4-yl)-1H-pyrazol-1-yl)-3-hydroxy-2,2-dimethylpropan-1-one

SMILES CC(C)(CO)C(=O)n1nc(C2CCOCC2)c(F)c1NCc1ccc(Cl)s1

InChI Key InChIKey=KEJQPLBDPVKEMM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 163397   

TargetProthrombin(Human)
Verseon

Curated by ChEMBL
LigandPNGBDBM163397(US9687479, 273 1-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human thrombin using S-2238 as chromogenic substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPlasma kallikrein(Human)
Verseon

US Patent
LigandPNGBDBM163397(US9687479, 273 1-(5-[(5-chlorothiophen-2-yl)methyl...)
Affinity DataIC50: 5.50E+4nMpH: 7.4 T: 2°CAssay Description:Human KLKB1 protein was obtained from Enzyme Research Labs. The chromogenic substrate S-2302 was obtained from DiaPharma. KLKB1 was assayed in buffer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2018
Entry Details
US Patent