BDBM16316 3-({4-[(2,2-dimethylpropyl)(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl}amino)-N-methoxy-4-methylbenzamide::CHEMBL225088::triaminotriazine aniline amide inhibitor, 1

SMILES CONC(=O)c1ccc(C)c(Nc2nc(nc(n2)N2CCCN(C)CC2)N(C)CC(C)(C)C)c1

InChI Key InChIKey=CFXVMISMBBBSCO-UHFFFAOYSA-N

Data  1 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 16316   

TargetProtein kinase C alpha type(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 44nMAssay Description:Inhibition of human p38-alpha expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Zap70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C delta type(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKCdeltaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IKK2betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataIC50: 22nMAssay Description:Inhibition of human p38betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM16316(CHEMBL225088 | 3-({4-[(2,2-dimethylpropyl)(methyl)...)
Affinity DataKi:  3.70nM ΔG°:  -11.4kcal/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2007
Entry Details Article
PubMed