BDBM162872 US9056859, 72

SMILES Cc1c2COC(=O)c2ccc1CCN1CCN(CC1)C(=O)Cc1ccc(nc1)-n1cnnn1

InChI Key InChIKey=PDBQDSXSCZPLNA-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 162872   

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 20nMpH: 7.4Assay Description:Block of Kir1.1 (ROMKI) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2016
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human ERG by electrophysiology analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetInward rectifier potassium channel 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kir2.3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetInward rectifier potassium channel 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kir2.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetVoltage-dependent P/Q-type calcium channel subunit alpha-1A(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cav2.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 60nMAssay Description:Inhibition of rat ROMK assessed as thallium flux after 30 mins in presence of ouabain by cell based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Rat)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 56nMAssay Description:Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 2.90E+4nMAssay Description:Displacement of [35S]-MK499 from human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM162872(US9056859, 72)
Affinity DataIC50: 20nMAssay Description:Inhibition of human ROMK expressed in CHO cells by whole-cell voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2017
Entry Details Article
PubMed