BDBM16281 2-({2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile::quinazolinone-based inhibitor 1j

SMILES COc1cc2c(cc1F)nc(N1CCC[C@@H](N)C1)n(Cc1ccccc1C#N)c2=O

InChI Key InChIKey=QYOZNVCKISSENR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16281   

TargetDipeptidyl peptidase 4(Human)
Takeda Pharmaceutical

LigandPNGBDBM16281(2-({2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-meth...)
Affinity DataIC50: 4nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2007
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Takeda Pharmaceutical

LigandPNGBDBM16281(2-({2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-meth...)
Affinity DataIC50: 1.00E+5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2007
Entry Details Article
PubMed