BDBM1624 2-ethyl-5-hydroxy-7-(hydroxymethyl)-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one::5,ll-Dihydro-1 l-ethy1-2-hydroxy-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2 ,3 -e][l,4]diazepin-6-one::Nevirapin 2,4-Disubstituted deriv. 12e

SMILES CCN1c2ncccc2C(=O)Nc2c(CO)cc(=O)[nH]c12

InChI Key InChIKey=CLDZYGDZKIMQFB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1624   

TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1624(2-ethyl-5-hydroxy-7-(hydroxymethyl)-2,4,9,15-tetra...)
Affinity DataIC50: 420nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2004
Entry Details Article
PubMed