BDBM162332 US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrazin-2-yl)piperazin-2-one

SMILES Cc1n[nH]c2ncc(cc12)-c1cncc(n1)N1CCNC(=O)C1

InChI Key InChIKey=WHDWSJMUGQYVEQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 162332   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162332(US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 500nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
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TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162332(US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 500nMAssay Description:Procedure: Enzyme was incubated with substrate peptide in reaction buffer in the presence and absence of test compounds or Staurosporine. All additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Arrien Pharmaceuticals

US Patent
LigandPNGBDBM162332(US9669028, 83 4-(6-(3-methyl-1H-pyrazolo[3,4-b]pyr...)
Affinity DataIC50: 500nMpH: 7.5Assay Description:The 2×DYRK1A/Ser/Thr 18 mixture was prepared in 50 mM HEPES pH 7.5, 0.01% BRIJ-35, 10 mM MgCl2, 1 mM EGTA. The final 10 μL Kinase Reaction consi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
Go to US Patent