BDBM162325 US10307427, Compound 16::US9051313, 16

SMILES C[C@H](n1cnnc1-c1nc(NC(=O)c2cc(c(cn2)N2CCN(C)CC2)-n2cnc(c2)C2CC2)cs1)C(F)(F)F

InChI Key InChIKey=GQWUPQVHSCGKAI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 162325   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gildead Sciences

US Patent
LigandPNGBDBM162325(US9051313, 16 | US10307427, Compound 16)
Affinity DataIC50: 2.10nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Gildead Sciences

US Patent
LigandPNGBDBM162325(US9051313, 16 | US10307427, Compound 16)
Affinity DataIC50: 2.10nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
Go to US Patent