BDBM162069 US9051279, 79

SMILES COc1cc2c(cc1OC(C)C)[C@H](c1ccc(Cl)cc1)N(c1ccc(N(C)C[C@H]3CC[C@H](N4CCNC(=O)C4)CC3)cc1)C(=O)C2

InChI Key InChIKey=BZZYIHQWCXHSMZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 162069   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 162069BDBM162069(US9051279, 79)
Affinity DataIC50: 1.60nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetProtein Mdm4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 162069BDBM162069(US9051279, 79)
Affinity DataIC50: 1.66E+3nMAssay Description:The inhibition of p53-Hdm2 and p53-Hdm4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/25/2016
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 162069BDBM162069(US9051279, 79)
Affinity DataIC50: 1.13E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 162069BDBM162069(US9051279, 79)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2016
Entry Details Article
PubMed