BDBM1618 2-ethyl-7-(hydroxymethyl)-5-methoxy-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one::5,ll-Dihydro- 11-ethyl-4-(hydroxymethyl)-2-methoxy-GH-dipyrid0[3,2-b:2 ,3 -e][ 1,4]diazepin-6-one::Nevirapin 2,4-Disubstituted deriv. 11e

SMILES CCN1c2nc(OC)cc(CO)c2NC(=O)c2cccnc12

InChI Key InChIKey=JYDIPPPAHISWJQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 1618   

TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM1618(5,ll-Dihydro- 11-ethyl-4-(hydroxymethyl)-2-methoxy...)
Affinity DataIC50: 50nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2004
Entry Details Article
PubMed